The Ontario Brain Research Institute (OBI) has announced the launch of the Brain-CODE neuroinformatics platform, which now offers open-access high-resolution magnetic resonance (MR) imaging data for mouse models. This groundbreaking initiative marks the first time such detailed imaging data is available to researchers, aiming to deepen our understanding of how autism impacts brain development and function. By accelerating research in this area, the platform supports the discovery of more effective treatments and improved health outcomes for individuals affected by autism.
The newly released dataset includes 31 mouse models representing 23 distinct genetic backgrounds from OBI’s ongoing Neurodevelopmental Disabilities Research Project (POND). The project, funded by the Ontario Brain Institute and supported by the Canadian Brain Program and the Canadian Institutes of Health Research, involves a team from Sick Children’s Hospital. These models are part of a larger effort that includes over 90 mouse models, providing valuable insights into neurodevelopmental conditions.
Collaborating with international research groups, the team collected MR images of mice with known genetic mutations linked to autism. These images help identify critical brain regions involved in autism, capture structural changes across different stages of development, and offer key insights into the neurological differences observed in autistic individuals. The availability of this data is expected to inspire researchers worldwide to explore new questions about how genetic factors contribute to brain network alterations in autism.
Brain-CODE is a comprehensive informatics platform developed and maintained by the Ontario Brain Institute. It serves as a centralized hub for collecting, storing, sharing, and analyzing data from various neuroscience research projects. To date, the platform has accumulated 16,140 records, including 14,610 human records and 1,530 animal records, covering areas such as cerebral palsy, depression, epilepsy, neurodegenerative diseases like Alzheimer's, and neurodevelopmental disorders such as autism. It also hosts datasets from other related studies.
All data within Brain-CODE is standardized, enabling researchers to compare datasets across different brain disorders. This standardization opens up new possibilities for exploring previously unanswerable questions, such as whether the depressive symptoms experienced by individuals with epilepsy or dementia differ in their underlying mechanisms. With this powerful tool, scientists can now investigate complex interactions between genetics, brain structure, and behavior in ways that were once unimaginable.
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